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“If you can’t explain it simply, you don’t understand it well enough.”
– Albert Einstein |
Patent US20100134605A1 (2010)
Developed in vivo endoscopic methods and prototypes for fluorescence and autofluorescence imaging. This enabled real-time diagnostics for early detection of abnormal tissues that may be indicative of disease
Peer Reviewed Publications
Lin, B., McMahan, C.G., Moerman, K.M., Pasch, K.A., Herr, H.M.
"Low-cost methodology for skin strain measurement of a flexed biological limb"
IEEE Transactions on Biomedical Engineering, Vol. 64, No. 12, pages 2750 - 2759: 2017
Lin, B., Urayama S., Saroufeem R.M. G., Matthews D.L., Demos S.G.
"Establishment of rules for interpreting ultraviolet autofluorescence microscopy images for non-invasive detection of Barrett’s esophagus and dysplasia"
Journal of Biomedical Optics, Vol. 16, No. 1, pages 1603-1 through 1603-10: 2012 [pdf]
Lin, B., Bergholt, M.S., Lau, D.P., Huang, Z.
“Diagnosis of early stage nasopharyngeal carcinoma using ultraviolet autofluorescence excitation–emission matrix spectroscopy and parallel factor analysis”
Analyst, Vo. 136, pages 3896 through 3903: 2011 [pdf]
Manuscript selected as a Chemistry World magazine news article, and inclusion in the “Analyst Journal Press Circular”
Lin, B., Urayama S., Saroufeem R.M. G., Matthews D.L., Demos S.G.
“Endomicroscopy imaging of epithelial structures using tissue autofluorescence”
Journal of Biomedical Optics, Vol. 16, No. 4, pages 046014-1 through 046014-7: 2011 [pdf]
Lin, B., Urayama S., Saroufeem R.M. G., Matthews D.L., Demos S.G.
"Characterizing the origin of autofluorescence in human esophageal epithelium under ultraviolet excitation"
Optics Express, Vol. 18, No. 20, pages 21075 through 21082: 2010 [pdf]
Lin, B., Urayama S., Saroufeem R.M. G., Matthews D.L., Demos S.G.
“Real-Time Microscopic Imaging of Esophageal Epithelial Disease with Autofluorescence under UV Excitation”
Optics Express, Vol. 17, No. 15, pages 12502 through 12509: 2009 [pdf]
Lin, B., Chernomordik V., Gandjbakhche A., Matthews D.L., Demos S.G.
“Investigation of signal dependence on tissue depth in near infrared spectral imaging”
Optics Express, Vol. 15, No. 25, pages 16581 through 16595: 2007 [pdf]
Demos S.G., Lieber C.A., Lin, B., Ramsamooj R.
“Imaging of Tissue Mictrostructures Using a Multimodal Microscope Design”
IEEE Vol. 11, No. 4, pages 752 through 758: 2005 [pdf]
Conference Proceedings
Invited Panelist: Asahi Symposium "Draw the Future" (Tokyo, Japan) October 2015
Invited Author: Photonics West, SPIE BiOS (San Francisco, California) January 2011
"Clinical translation of ultraviolet autofluorescence microscopy towards endomicroscopy for early detection of cancer"
SPIE Proceedings Vol. 7990, Optical Sensors and Biophotonics II, 799002, doi: 10.1117/12.888682
Invited Author: Asia Communications & Photonics Conference (Shanghai, China) December 2010
“Clinical Translation of UV Autofluorescence Microscopy towards Endomicroscopy for Early Detection of Cancer”
IEEE doi: 10.1109/ACP.2010.5682843 Pages 44 through 45
Invited: University of California, Merced (Merced, California) April 2010
"Bioengineering in the development of medical diagnostic systems using ultraviolet autofluorescence"
Biological Engineering & Small-Scale Technologies, Quantitative & Systems Biology Seminar Series
Photonics West, SPIE BiOS (San Francisco, California) January 2010
“Visualization of epithelial morphology using autofluorescence microscopy under ultraviolet excitation”
SPIE Proceedings Vol. 7561, Optical Biopsy VII, 756103, doi:10.1117/12.840715
National Institutes of Health, (Bethesda, Maryland) October 2009
“Investigation of Autofluorescence Microscopy for In Vivo Imaging of Esophageal Adenocarcinoma”
Optical Diagnostic Imaging from Bench to Bedside
Invited: University of California, Merced (Merced, California) October 2009
"Ultraviolet Autofluorescence microscopy provides real-time histopathology for esophageal disease"
School of Natural Sciences Physics Seminar Series
CLEO IQEC (Baltimore, Maryland) June 2009
“Autofluorescence Microscopy for Real-Time Imaging of Human Esophageal Disease”
IEEE Proceedings E-ISBN : 978-1-55752-869-8, Pages 1 - 2
Digestive Disease Week AASLD, AGA, ASGE, SSAT (Chicago, Illinois) June 2009
“Ex vivo Imaging of Esophageal Neoplasm using Autofluorescence Microscopy”
OSA BioMed (Saint Petersburg, Florida) March 2008
“Lesion Thickness Assessment Using a Fiber Optic Probe”
OSA Technical Digest, BTuF42, doi:10.1364/BIOMED.2008.BTuF42
Photonics West, SPIE BiOS (San Jose, California) January 2008
“Evaluation of Optical Imaging and Spectroscopy Approaches for Cardiac Tissue Depth Assessment”
SPIE Proceedings Vol. 6864, Biomedical Applications of Light Scattering II, doi: 10.1117/12.763660
SPIE/OSA European Conferences on Biomedical Optics (Munich, Germany) June 2007
“Cardiac Tissue Characterization Via Optical Spectroscopy Techniques”
Proceedings of SPIE Vol. 6628-S3
IEEE 40th Asilomar Conference on Signals, Systems and Computer (Pacific Grove, California) October 2006
“Multimodal microscopy for in vivo imaging of tissue microstructures”
Photonics West, SPIE BiOS (San Jose, California) January, 2006
“Real-time Imaging of Tissue Microstructures Using Intrinsic Optical Signatures”
SPIE Proceedings Vol. 6091, Optical Biopsy VI, doi: 10.1117/12.644954
CLEO IQEC (Baltimore, Maryland) May 2005
"Imaging intact tissue microstructures using a multimodal, high-resolution microscope"
IEEE Proceedings Vol. 2 Pages: 1363 - 1365, doi: 10.1109/CLEO.2005.202126
Abstracts and Poster Presentations
Center for Biophotonics Science and Technology Spring Science Workshop (Sacramento, California) April 2010
“Clinical Translation of UV Autofluorescence Microscopy using Bench-top Endomicroscopy”
Gastrointestinal Endoscopy, Vol. 69, Issue 5: 2009
“Ex vivo Imaging of Esophageal Neoplasm using Autofluorescence Microscopy”
Center for Biophotonics Science and Technology Spring Workshop (Sacramento, California) March 2008
“Real-time Autofluorescence Imaging of Tissue Microstructures”
3rd Biophotonics Symposium, University of Texas, (San Antonio, Texas) March 2008
“Lesion Thickness Assessment using a Fiber Optic Probe”
Center for Biophotonics Science and Technology Annual Retreat Squaw Valley (Tahoe, California) July 2007
“Cardiac Tissue Characterization Via Optical Spectroscopy Techniques”
Center for Biophotonics Science and Technology Spring Workshop (Sacramento, California) March 2007
“Advanced endoscopy and tissue biopsy”
National Institutes of Health Optical Diagnostic Imaging from Bench to Bedside, (Bethesda, Maryland) September 2006
“Real-time Imaging of Tissue Microstructures Using Intrinsic Optical Signatures” Poster #65
Biomedical Engineering Graduate Group Retreat, (Point Reyes, California) June 2006
“Real-time Imaging of Tissue Microstructures Using Intrinsic Optical Signatures”
Center for Biophotonics Science and Technology 3rd Annual Center Wide Retreat, Squaw Valley (Tahoe, CA) July 2005
“In Vivo Cancer Detection using a Multimodal, High-Resolution Microscope”
Lawrence Berkeley National Laboratory (Berkeley, CA) October 2004
New Directions-Women of Influence in the National Laboratories, Laboratory Women's Technical Forum
Invited Journal Reviewer
Journal of Biomedical Optics
Optics Express
Digestive Diseases and Science
Histology and Histopathology
Medical & Biological Engineering and Computing
Developed in vivo endoscopic methods and prototypes for fluorescence and autofluorescence imaging. This enabled real-time diagnostics for early detection of abnormal tissues that may be indicative of disease
Peer Reviewed Publications
Lin, B., McMahan, C.G., Moerman, K.M., Pasch, K.A., Herr, H.M.
"Low-cost methodology for skin strain measurement of a flexed biological limb"
IEEE Transactions on Biomedical Engineering, Vol. 64, No. 12, pages 2750 - 2759: 2017
Lin, B., Urayama S., Saroufeem R.M. G., Matthews D.L., Demos S.G.
"Establishment of rules for interpreting ultraviolet autofluorescence microscopy images for non-invasive detection of Barrett’s esophagus and dysplasia"
Journal of Biomedical Optics, Vol. 16, No. 1, pages 1603-1 through 1603-10: 2012 [pdf]
Lin, B., Bergholt, M.S., Lau, D.P., Huang, Z.
“Diagnosis of early stage nasopharyngeal carcinoma using ultraviolet autofluorescence excitation–emission matrix spectroscopy and parallel factor analysis”
Analyst, Vo. 136, pages 3896 through 3903: 2011 [pdf]
Manuscript selected as a Chemistry World magazine news article, and inclusion in the “Analyst Journal Press Circular”
Lin, B., Urayama S., Saroufeem R.M. G., Matthews D.L., Demos S.G.
“Endomicroscopy imaging of epithelial structures using tissue autofluorescence”
Journal of Biomedical Optics, Vol. 16, No. 4, pages 046014-1 through 046014-7: 2011 [pdf]
Lin, B., Urayama S., Saroufeem R.M. G., Matthews D.L., Demos S.G.
"Characterizing the origin of autofluorescence in human esophageal epithelium under ultraviolet excitation"
Optics Express, Vol. 18, No. 20, pages 21075 through 21082: 2010 [pdf]
Lin, B., Urayama S., Saroufeem R.M. G., Matthews D.L., Demos S.G.
“Real-Time Microscopic Imaging of Esophageal Epithelial Disease with Autofluorescence under UV Excitation”
Optics Express, Vol. 17, No. 15, pages 12502 through 12509: 2009 [pdf]
Lin, B., Chernomordik V., Gandjbakhche A., Matthews D.L., Demos S.G.
“Investigation of signal dependence on tissue depth in near infrared spectral imaging”
Optics Express, Vol. 15, No. 25, pages 16581 through 16595: 2007 [pdf]
Demos S.G., Lieber C.A., Lin, B., Ramsamooj R.
“Imaging of Tissue Mictrostructures Using a Multimodal Microscope Design”
IEEE Vol. 11, No. 4, pages 752 through 758: 2005 [pdf]
Conference Proceedings
Invited Panelist: Asahi Symposium "Draw the Future" (Tokyo, Japan) October 2015
Invited Author: Photonics West, SPIE BiOS (San Francisco, California) January 2011
"Clinical translation of ultraviolet autofluorescence microscopy towards endomicroscopy for early detection of cancer"
SPIE Proceedings Vol. 7990, Optical Sensors and Biophotonics II, 799002, doi: 10.1117/12.888682
Invited Author: Asia Communications & Photonics Conference (Shanghai, China) December 2010
“Clinical Translation of UV Autofluorescence Microscopy towards Endomicroscopy for Early Detection of Cancer”
IEEE doi: 10.1109/ACP.2010.5682843 Pages 44 through 45
Invited: University of California, Merced (Merced, California) April 2010
"Bioengineering in the development of medical diagnostic systems using ultraviolet autofluorescence"
Biological Engineering & Small-Scale Technologies, Quantitative & Systems Biology Seminar Series
Photonics West, SPIE BiOS (San Francisco, California) January 2010
“Visualization of epithelial morphology using autofluorescence microscopy under ultraviolet excitation”
SPIE Proceedings Vol. 7561, Optical Biopsy VII, 756103, doi:10.1117/12.840715
National Institutes of Health, (Bethesda, Maryland) October 2009
“Investigation of Autofluorescence Microscopy for In Vivo Imaging of Esophageal Adenocarcinoma”
Optical Diagnostic Imaging from Bench to Bedside
Invited: University of California, Merced (Merced, California) October 2009
"Ultraviolet Autofluorescence microscopy provides real-time histopathology for esophageal disease"
School of Natural Sciences Physics Seminar Series
CLEO IQEC (Baltimore, Maryland) June 2009
“Autofluorescence Microscopy for Real-Time Imaging of Human Esophageal Disease”
IEEE Proceedings E-ISBN : 978-1-55752-869-8, Pages 1 - 2
Digestive Disease Week AASLD, AGA, ASGE, SSAT (Chicago, Illinois) June 2009
“Ex vivo Imaging of Esophageal Neoplasm using Autofluorescence Microscopy”
OSA BioMed (Saint Petersburg, Florida) March 2008
“Lesion Thickness Assessment Using a Fiber Optic Probe”
OSA Technical Digest, BTuF42, doi:10.1364/BIOMED.2008.BTuF42
Photonics West, SPIE BiOS (San Jose, California) January 2008
“Evaluation of Optical Imaging and Spectroscopy Approaches for Cardiac Tissue Depth Assessment”
SPIE Proceedings Vol. 6864, Biomedical Applications of Light Scattering II, doi: 10.1117/12.763660
SPIE/OSA European Conferences on Biomedical Optics (Munich, Germany) June 2007
“Cardiac Tissue Characterization Via Optical Spectroscopy Techniques”
Proceedings of SPIE Vol. 6628-S3
IEEE 40th Asilomar Conference on Signals, Systems and Computer (Pacific Grove, California) October 2006
“Multimodal microscopy for in vivo imaging of tissue microstructures”
Photonics West, SPIE BiOS (San Jose, California) January, 2006
“Real-time Imaging of Tissue Microstructures Using Intrinsic Optical Signatures”
SPIE Proceedings Vol. 6091, Optical Biopsy VI, doi: 10.1117/12.644954
CLEO IQEC (Baltimore, Maryland) May 2005
"Imaging intact tissue microstructures using a multimodal, high-resolution microscope"
IEEE Proceedings Vol. 2 Pages: 1363 - 1365, doi: 10.1109/CLEO.2005.202126
Abstracts and Poster Presentations
Center for Biophotonics Science and Technology Spring Science Workshop (Sacramento, California) April 2010
“Clinical Translation of UV Autofluorescence Microscopy using Bench-top Endomicroscopy”
Gastrointestinal Endoscopy, Vol. 69, Issue 5: 2009
“Ex vivo Imaging of Esophageal Neoplasm using Autofluorescence Microscopy”
Center for Biophotonics Science and Technology Spring Workshop (Sacramento, California) March 2008
“Real-time Autofluorescence Imaging of Tissue Microstructures”
3rd Biophotonics Symposium, University of Texas, (San Antonio, Texas) March 2008
“Lesion Thickness Assessment using a Fiber Optic Probe”
Center for Biophotonics Science and Technology Annual Retreat Squaw Valley (Tahoe, California) July 2007
“Cardiac Tissue Characterization Via Optical Spectroscopy Techniques”
Center for Biophotonics Science and Technology Spring Workshop (Sacramento, California) March 2007
“Advanced endoscopy and tissue biopsy”
National Institutes of Health Optical Diagnostic Imaging from Bench to Bedside, (Bethesda, Maryland) September 2006
“Real-time Imaging of Tissue Microstructures Using Intrinsic Optical Signatures” Poster #65
Biomedical Engineering Graduate Group Retreat, (Point Reyes, California) June 2006
“Real-time Imaging of Tissue Microstructures Using Intrinsic Optical Signatures”
Center for Biophotonics Science and Technology 3rd Annual Center Wide Retreat, Squaw Valley (Tahoe, CA) July 2005
“In Vivo Cancer Detection using a Multimodal, High-Resolution Microscope”
Lawrence Berkeley National Laboratory (Berkeley, CA) October 2004
New Directions-Women of Influence in the National Laboratories, Laboratory Women's Technical Forum
Invited Journal Reviewer
Journal of Biomedical Optics
Optics Express
Digestive Diseases and Science
Histology and Histopathology
Medical & Biological Engineering and Computing